Hesperidin and Diosmin

Sedentary lifestyle, bad habits and hereditary predisposition lead to serious problems with venous diseases. Vein
diseases are a consequence of unpleasant painful sensations and cosmetic defects. To combat these pathologies, various
drugs are used, including plant origin.

Very popular among doctors are preparations based on hesperidin and diosmin. Further you will learn what these
substances are useful, to whom and why they are prescribed.

Hesperidin – general characterization

Hesperidin (hesperidin) is a natural bioflavonoid that belongs to the group of vitamin P. The compound was first
isolated by Lebreton from the rind of ripe citrus fruits.
isolated by Lebreton from the rind of immature citrus fruits. In terms of chemical structure, hesperidin belongs to
flavones and has no optical isomers.
and has no optical isomers. In its pure form it is a colorless crystalline powder with a slight specific odor. В
preparations should contain at least 90% of it.

Diosmin – general characterization

Diosmin (diosmin) is another representative of flavonoid compounds. It is a semi-synthetic substance. To
To obtain the compound, scientists use natural hesperidin, the structural formula of which is subjected to a series of
chemical
transformations. In order to increase the bioavailability of the substance, it is transformed into a micronized form –
reduce the size of the particles.
particle size.

Natural sources

Hesperidin is found in a variety of citrus fruits. Most of the compound is found in the peel of the fruit and about
10-15%
– in the pericarp and seeds. The largest amount of hesperidin contains:

• unripe oranges;
• tangerines;
• Hybrid fruit obtained by crossing oranges and tangerines.

Small concentrations of the substance contain extracts of valerian, condopsis flowers, bomeria whitensis, etc. These
natural
sources are not used for industrial production of medicinal supplements. Diosmin is not found in nature, it can only be
obtained
can be obtained only after processing of hesperidin.

Effects on the body

The beneficial effects and properties of natural hesperidin and the synthetic compound diosmin are greatly enhanced when
these substances are used simultaneously. Therefore, the nutrients are hardly ever used separately. Flavonoids
enhance the vasoconstrictive effects of the hormone and neurotransmitter norepinephrine. As a result, vein wall tone
increases,
reduces venous capacity and blood stasis in the distal lower extremities. Bioflavonoids reverse the vascular damage
vessels observed in patients with chronic venous insufficiency.

In addition to venotonic action, flavonoid compounds have other effects:

• increase the intensity of lymphatic vessel contraction and improve lymphatic outflow, so that the swelling of the legs
  goes away faster
  swelling of the legs;
• reduce capillary permeability and reduce their fragility, so the vessels of the microcirculatory channel retain the
  integrity;
• make venous walls more resistant to the harmful effects of free radicals and reactive oxygen species;
• reduce the concentration of pro-inflammatory prostaglandins and cytokines, reduce pain syndrome;
• prevent the risk of bleeding in women using an IUD as a contraceptive method.
  contraceptive method.

Medical applications

Doctors use preparations containing flavonoids hesperidin and diosmin for various venous lesions.
There are venotonics for local use – in the form of gels and ointments. We’re going to talk mainly about agents
for oral use. They are available in 3 forms: solid tablets, gelatin-coated capsules and suspension.

For varicose veins

The drugs are prescribed to relieve unpleasant symptoms of varicose veins, such as:

• a feeling of heaviness and fatigue in the legs;
• calf muscle pain;
• swelling of the feet and lower legs in the evening;
• the appearance of vascular asterisks;
• swollen veins.

With regular use of medicines containing hesperidin and diosmin, there is a strengthening of the venous wall and
slows down the progression of varicose veins. Patients get rid of distressing symptoms and can return to a normal
life.

For hemorrhoids

The main effect of flavonoids is to increase the tone of hemorrhoidal nodes. After taking the medication, there’s less
blood congestion of veins in the anus area, problems with defecation disappear. With prolonged use of the active
ingredient
Hesperidin vein walls become strong, bleeding occurs much less often. The drugs also stop the inflammatory
process and have a pronounced analgesic effect.

For the treatment of trophic ulcers

Flavonoid compounds have pronounced regenerative properties. They reduce the area and depth
of trophic ulcers. Hesperedin also improves blood flow in the affected area, so that wound healing is much faster, and
eliminates acute pain.
much faster and eliminates acute pain.

Before and after vein surgery

Complexes of bioflavonoids are used in preparation for vein surgeries or elimination of hemorrhoids. Means accelerate
tissue healing, prevent recurrence of the disease.

Use hesperidin and in the postoperative period. Drugs increase peripheral vascular resistance,
prevent orthostatic hypotension, reduce leg swelling, used after prolonged bed rest, and
for the prevention of venous insufficiency. Proven ability of flavonoids to prevent bleeding in patients after
phlebectomy.